clippers syndrome
Epub 2010 Jul 17.Scott Med J. 2016 Sep;68(9):1069-1080. doi: 10.11477/mf.1416200554.Hou X, Wang X, Xie B, Lin W, Liu J, Ma D, Zhang HL.Medicine (Baltimore). 2014;54(7):581-4. doi: 10.5692/clinicalneurol.54.581.Pittock SJ, Debruyne J, Krecke KN, Giannini C, van den Ameele J, De Herdt V, McKeon A, Fealey RD, Weinshenker BG, Aksamit AJ, Krueger BR, Shuster EA, Keegan BM.Brain. Clipboard, Search History, and several other advanced features are temporarily unavailable. Brain magnetic resonance imaging (MRI) of a patient with CLIPPERS (chronic lymphocytic inflammation… Diagnosis of CLIPPERS is challenging, and requires careful exclusion of alternative diagnoses. Clinicians and radiologists should be aware of this condition and its differential diagnoses, given that CLIPPERS constitutes a treatable condition and that patients may benefit from an early introduction of GCS ensued by long-term immunosuppression. [1] Es handelt sich um eine Erkrankung des Immunsystems, bei der der Hirnstamm von körpereigenen Lymphozyten angegriffen wird.
eCollection 2019 May.
2019 Feb 1;6(3):e545.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a treatable inflammatory disease of the central nervous system.Specifically, it is a type of encephalomyelitis, which is a general term describing inflammation of the brain and spinal cord. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently defined inflammatory central nervous system (CNS) disorder, prominently involving the brainstem and in particular the pons. 2019 Nov 4;19(1):266. doi: 10.1186/s12883-019-1507-z.Vola E, Russo C, Macera A, Del Vecchio W, Puoti G, Caranci F, Elefante A.Eur J Radiol Open.
Tani H, Nakajima H, Yamane K, Ohnishi H, Kimura F, Hanafusa T.Rinsho Shinkeigaku. Introduction.
It has a predilection for the pons, with fairly characteristic curvilinear regions of enhancement best seen on MRI. As withdrawal of GCS treatment results commonly in disease exacerbation, long-term immunosuppressive therapy appears to be mandatory for sustained improvement. No vasculitic angiographic changes (i.e. This site needs JavaScript to work properly. Epub 2020 Jan 10.Liu XH, Jin F, Zhang M, Liu MX, Wang T, Pan BJ, Zhang L.BMC Neurol. Figures reproduced from [25], with kind permission of Springer Science + Business Media. Another core feature is clinical and radiological responsiveness to glucocorticosteroid (GCS)-based immunosuppression. Whether CLIPPERS represents an independent, actual new disorder or a syndrome that includes aetiologically heterogeneous diseases and/or their prestages remains a debated and not finally clarified issue. doi: 10.1097/MD.0000000000004640.Kamişli Ö, Tecellioğlu M, Erbay MF, Kamişli S, Özcan C.Noro Psikiyatr Ars. Diagnosis of CLIPPERS is based on clinical, radiological, laboratory and CSF investigations and, if necessary, brain biopsy. 2017 Nov 8;57(2):160-164. doi: 10.5152/npa.2017.22732. 2019 Jun 6;6:212-214. doi: 10.1016/j.ejro.2019.05.005. Typische Symptome sind ein Kribbeln im Kopf und Taubheitsgefühle. The protocol should include contrast. Free PMC article 2017 Feb;62(1):28-33. doi: 10.1177/0036933016689006. Brain magnetic resonance imaging (MRI) of a patient with CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) (coronar post-contrast T1-weighted images). CLIPPERS has been reported in a wide range of ages (13 to 86 years) but generally is seen in middle age Patients typically present subacutely with a wide variety of signs and symptoms dominated by Generally, patients remain cognitively intact and do not suffer from other signs of inflammation (e.g.
fevers or sweats or meningism) These lesions histologically demonstrate a lymphocytic perivascular inflammatory pattern MRI is the imaging modality of choice for the assessment of patients with suspected brainstem pathology.
Please enable it to take advantage of the complete set of features! The condition features a combination of clinical symptoms essentially referable to brainstem pathology and a characteristic magnetic resonance imaging (MRI) appearance with punctate and curvilinear gadolinium enhancement 'peppering' the pons. Pathogenesis of CLIPPERS remains poorly understood, and the nosological position of CLIPPERS has still to be established. Based on previous reports in literature - currently encompassing more than 50 reported cases of CLIPPERS - this review addresses clinical features, diagnostic criteria, differential diagnoses and therapeutic management of this peculiar disorder.
It affects both genders with possibly a minor male predominance.
(b) Progression of gadolinium-enhancing lesions 6 weeks later. Wiley
Beim Clippers-Syndrom greifen Abwehrzellen des Immunsystems den Hirnstamm an. Unable to load your collection due to an error no beading) are reported Susceptibility weighted imaging can reveal prominent veins and punctate regions of signal loss Patients typically respond rapidly to the administration of glucocorticosteroids but have a tendency to relapse if immunosuppression is ceased.
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