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The management of melasma is challenging and requires a long-term treatment plan. What Are the Different Classes of Stem Cells and Benefits of Each. How: Similar to the way PRP is done, donor stem cells (typically human stem cells from an infant’s umbilical cord) are injected into the designated treatment area. Multiple sclerosis, rheumatoid arthritis and lupus have been successfully treated in human clinical trials. Gene Ther 2003;10:1099-104. Regenerative therapy for the management of a large skin wound in a dog. Mathor MB, Ferrari G, Dellambra E, Cilli M, Mavilio F, Cancedda R, Mullen CA, Snitzer K, Culver KW, Morgan RA, Anderson WF, Blaese RM. Stem cell therapy in veterinary dermatology. Int J Biochem Cell Biol 2010;42:1094-104. Google Scholar. Drug Des Devel Ther 2015;9:4219-25. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma. Melanocyte biology and skin pigmentation. Indian J Dermatol 2015;60:520. Robbins PB, Khavari PA. Strategies for cutaneous gene therapy. Background: J Invest Dermatol 2004;122:549-51. Med Hypotheses 2017;101:1-5. Rashmi Sarkar, Anuva Bansal, Pallavi Ailawadi What: “I think of stem cell therapy as PRP on steroids,” says Dr. Goldenberg. Grimes PE. It’s very resilient and can withstand quite a beating. This is where stem cell therapy can and will come into play. J Cutan Aesthet Surg 2013;6:4-11. J Invest Dermatol 1999;113:375-83. Adult stem cells come from many sources and have the capacity to differentiate into many cell types, including those of the skin. Proc Natl Acad Sci USA 1991;88:1330-4. Springer: Hydelburg, Germany; 2001. Nat Med 1996;2:1211-6. Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y. Ilknur T, Biçak MU, Demirtaşoǧlu M, Ozkan S. Glycolic acid peels versus amino fruit acid peels in the treatment of melasma. Proteggente AR, Basu-Modak S, Kuhnle G, Gordon MJ, Youdim K, Tyrrell R. Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T. Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation. Published by Elsevier Taiwan LLC. (Try These Skin-Care Products to Help Protect Against Pollution.). Terron A, McLean WH. High efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. Shape may receive compensation when you click through and purchase from links contained on Stem cell – Wikipedia, the free encyclopedia – Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. Veterinary Dermatology © 2013 ESVD and ACVD. Indian J Dermatol Venereol Leprol 2012;78:417-28. Adalatkhah H, Sadeghi-Bazargani H. The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: A randomized clinical trial. Sanchez NP, Pathak MA, Sato S, Fitzpatrick TB, Sanchez JL, Mihm MC Jr. Melasma: A clinical, light microscopic, ultrastructural, and immunofluorescence study. 2011; 21(6): 323-324, Current Trends in Biotechnology and Pharmacy. Kim EH, Kim YC, Lee ES, Kang HY. Pigment Cell Melanoma Res 2009;22:420-34. A new wave of treatments and products improves your complexion today—and how it behaves in the future. Epub 2015 May 26. Hengge UR, Volc-Platzer B. Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. J Drugs Dermatol 2007;6:917-22. Zinc therapy in dermatology: A review. Kang HY, Ortonne JP. A partial catalogue of proteins secreted by epidermal keratinocytes in culture. Did you know that stem cells are even useful in dermatology? 2002 Dec 10;82(23):1632-6. J Am Acad Dermatol 2016;75:385-92. Future therapies in melasma: What lies ahead? Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients. Of course, it’s a little more complicated than that but, that’s the basics of what stem cell therapy involves. Paine C, Sharlow E, Liebel F, Eisinger M, Shapiro S, Seiberg M. Smit N, Vicanova J, Pavel S. The hunt for natural skin whitening agents. Maeda K, Tomitab Y. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Genome maintenance mechanisms for preventing cancer. Development 2000;127:5379-89. Curcumin targeted signaling pathways: Basis for anti-photoaging and anti-carcinogenic therapy. Target sub-population of cells: Role of stem cell Studies proved that gene therapy targeting stem cells offer longer duration of gene expression than other cells because, with cell divisions, such stem cells are not depleted. (Related: Why Laser and Light Treatments Are Really Good for Your Skin). 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